538773 Nitric Oxide Production Inhibitor, 8-Gly Carb - Calbiochem

538773
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₃H₁₁ClN₄O.CF₃CH₂O

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable carboline derived compound that acts as an inhibitor of both the constitutive (IC50 = 7 µM) and the inducible (IC50 = 7 µM and 20 µM for TNFalpha and LPS-induced) production of nitric oxide (·NO) in rat peritoneal macrophages in a manner independent of NF-κB activation. Only at higher concentrations (~ 100 µM), it inhibits NF-κB-mediated gene expression in differentiated THP1-XBlue cells. Shown to be about 40-fold more effective than NG-nitro-L-arginine in inhibiting ·NO production and 15-fold more effective in blocking LPS-induced ·NO production. Does not affect LPS- or TNFalpha-mediated cytokine production in THP1-XBlue cells and has no effect on ERK1/2 and p38 phosphorylation in TNFalpha stimulated THP1-XBlue cells.
      Catalogue Number538773
      Brand Family Calbiochem®
      Synonyms2-Amino-N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)acetamide Trifluoroacetate, NO Inhibitor, 8-Gly Carb
      References
      ReferencesGrodzki, A.C., et al. 2015. J. Pharm. Exp. Ther. 352, 438.
      Product Information
      FormBeige solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃H₁₁ClN₄O.CF₃CH₂O
      Chemical formulaC₁₃H₁₁ClN₄O.CF₃CH₂O
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Nitric Oxide Production Inhibitor, 8-Gly Carb - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Grodzki, A.C., et al. 2015. J. Pharm. Exp. Ther. 352, 438.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-July-2017 JSW
      Synonyms2-Amino-N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)acetamide Trifluoroacetate, NO Inhibitor, 8-Gly Carb
      DescriptionA cell-permeable carboline derived compound that acts as an inhibitor of both the constitutive (IC50 = 7 µM) and the inducible (IC50 = 7 µM and 20 µM for TNFalpha and LPS-induced) production of nitric oxide (·NO) in rat peritoneal macrophages in a manner independent of NF-κB activation. Only at higher concentrations (~ 100 µM), it inhibits NF-κB-mediated gene expression in differentiated THP1-XBlue cells. Shown to be about 40-fold more effective than NG-nitro-L-arginine in inhibiting ·NO production and 15-fold more effective in blocking LPS-induced ·NO production. Does not affect LPS- or TNFalpha-mediated cytokine production in THP1-XBlue cells and has no effect on ERK1/2 and p38 phosphorylation in TNFalpha stimulated THP1-XBlue cells.
      FormBeige solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₁ClN₄O.CF₃CH₂O
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrodzki, A.C., et al. 2015. J. Pharm. Exp. Ther. 352, 438.