NS110 Neurotrophin Antibody Set Trial Pack 1, Contains 100 µg each of Sheep IgG Fraction anti-BDNF, NGF, NT3, NT4/5

NS110
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      Overview

      Replacement Information
      Description
      Catalogue NumberNS110
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionNeurotrophin Antibody Set Trial Pack 1, Contains 100 µg each of Sheep IgG Fraction anti-BDNF, NGF, NT3, NT4/5
      OverviewThe fate of many neurons in the developing and adult nervous system is controlled partly by neurotrophins. This family of proteins include Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor (BDNF), Neurotrophin 3 (NT3) and Neurotrophin 4/5 (NT4/5). Neurotrophins are known to regulate the survival and differentiation of selective populations of neurons during embryonic development and maintenance of specific function in adulthood. The secretion of neurotrophins supports the selection of neurons during the thinning of neuronal population by programmed cell death (apoptosis). However, the roles of these neurotrophic factors in the brain and peripheral tissues are not very well understood. Therefore the availability of antibodies capable of neutralizing each neurotrophin will greatly aid further exploration of the action of these factors.

      Immunogen: Mouse nerve growth factor-beta purified from salivary glands. Antigen purity greater than 95% by PAGE.
      References
      Product Information
      FormatPurified
      PresentationProtein G purified immunoglobulins from sheep.
      Applications
      ApplicationThis Antibody pack contains anti-BDNF Antibody, anti-NGF Antibody, anti-NT3 Antibody, anti-NT4/5 Antibody validated for use in ELISA, WB & IHC.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry
      • Affects Function
      Application NotesImmunohistochemistry: 1-10 μg/mL (protocol available on individual datasheets, see individual catalog numbers).

      Immunoblotting: 1-10 μg/mL

      ELISA: 1-10 μg/mL

      Inhibition of biological activity in vitro: 1-10 μg/mL

      Optimal working dilutions must be determined by the end user.
      Biological Information
      HostSheep
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood.
      Gene Symbol
      • BDNF
      • Abrineurin
      • neurotrophin
      • MGC34632
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P34130 # Target-derived survival factor for peripheral sensory sympathetic neurons.
      SIZE: 210 amino acids; 22427 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
      SIMILARITY: SwissProt: P34130 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20 to -70°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
      Packaging Information
      Material Size1 kit
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Neurotrophin Antibody Set Trial Pack 1, Contains 100 µg each of Sheep IgG Fraction anti-BDNF, NGF, NT3, NT4/5 Certificates of Analysis

      TitleLot Number
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 12474831
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 1 - 21399722139972
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 1 - 21450392145039
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 1 - 21482032148203
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 1 - 22071432207143
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 1 - 22280652228065
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 1 - NG1853921NG1853921

      Data Sheet

      Title
      ANTI-NEUROTROPHIN ANTIBODY SAMPLE PACK 1