480748 Sigma-AldrichNeuronal Differentiation Inducer, Isobavachin - Calbiochem
A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.
More>> A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one
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Overview
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Key Specifications Table
| Empirical Formula |
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| C₂₀H₂₀O₄ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 480748-5MG |
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Glass bottle | 5 mg |
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| Description | |
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| Overview | A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000 nM), a Geranylgeranyltransferase I Inhibitor (Cat. No. 345883) selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation. |
| Catalogue Number | 480748 |
| Brand Family | Calbiochem® |
| Synonyms | Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one |
| References | |
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| References | Wang, D.Y., et al. 2011. Acta Pharmacol Sin 32, 425. |
| Product Information | |
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| Form | Pale yellow solid |
| Hill Formula | C₂₀H₂₀O₄ |
| Chemical formula | C₂₀H₂₀O₄ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Safety Information |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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Documentation
Neuronal Differentiation Inducer, Isobavachin - Calbiochem SDS
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Neuronal Differentiation Inducer, Isobavachin - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 480748 |
References
| Reference overview |
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| Wang, D.Y., et al. 2011. Acta Pharmacol Sin 32, 425. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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