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480748 Neuronal Differentiation Inducer, Isobavachin - Calbiochem

A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one

480748
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₂₀O₄

Pricing & Availability

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480748-5MG
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      Description
      OverviewA cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000 nM), a Geranylgeranyltransferase I Inhibitor (Cat. No. 345883) selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation.
      Catalogue Number480748
      Brand Family Calbiochem®
      SynonymsIsobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one
      References
      ReferencesWang, D.Y., et al. 2011. Acta Pharmacol Sin 32, 425.
      Product Information
      FormPale yellow solid
      Hill FormulaC₂₀H₂₀O₄
      Chemical formulaC₂₀H₂₀O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Neuronal Differentiation Inducer, Isobavachin - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Neuronal Differentiation Inducer, Isobavachin - Calbiochem Certificates of Analysis

      TitleLot Number
      480748

      References

      Reference overview
      Wang, D.Y., et al. 2011. Acta Pharmacol Sin 32, 425.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-July-2012 JSW
      SynonymsIsobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one
      DescriptionA cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100 nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000 nM), a Geranylgeranyltransferase I Inhibitor (Cat. No. 345883) selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₀O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml; clear, yellow solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, D.Y., et al. 2011. Acta Pharmacol Sin 32, 425.