GF220 Neurite growth protein L1

GF220
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SpeciesSourcePurity
      Human Mammalian cells, HEK293 cell line
      • Greater than 90% by SDS-PAGE and Coomassie blue staining.
      • Fig 1. Western blotting by primary antibody rat anti L1 (Millipore Corp, cat. # MAB5272) and secondary antibody goat anti rat, HRP (Millipore Corp, cat. # AP183P). Single band expected at ~ 200 kDa
      Description
      Catalogue NumberGF220
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionNeurite growth protein L1
      Background InformationL1, a cell adhesion molecule of the Ig superfamily (IgCAM) plays a critical role in the formation of neuronal networks. This is reflected by the variety of clinical signs associated with the X-linked recessive neurological disorder that is caused by mutations in the L1 gene. L1 regulates the formation of axon fascicles and promotes neurite outgrowth through interaction with a wide spectrum of binding partners including cell adhesion molecules and extra-cellular matrix components. L1 participates in the signaling of a secreted guidance cue of the Semaphorin family, Sema3A. Three types of experimental evidence support L1 as a key component of the Sema3A receptor complex.

      Chimeric protein of Human neurite growth protein L1 and Human IgG-Fc γ domain purified using protein A-agarose (Millipore Corp, cat. # 16-125). MW ~ 200 kDa.
      References
      Product Information
      Presentation100 µg of recombinant protein in 100µl of 1X PBS, 20%(v/v) glycerol. Frozen solution.
      Quality LevelMQ100
      Applications
      ApplicationThe Neurite Growth Protein L1 is a cell adhesion molecule of the Ig superfamily (IgCAM) plays a critical role in the formation of neuronal networks.
      Application NotesUsed at 5 μg/ml (see references 1 and 2).
      Optimal working concentration must be determined by end user.
      Biological Information
      Concentration1 mg/mL
      Purity
      • Greater than 90% by SDS-PAGE and Coomassie blue staining.
      • Fig 1. Western blotting by primary antibody rat anti L1 (Millipore Corp, cat. # MAB5272) and secondary antibody goat anti rat, HRP (Millipore Corp, cat. # AP183P). Single band expected at ~ 200 kDa
      SourceMammalian cells, HEK293 cell line
      Specific ActivitySee references.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsShipped on dry ice. Best stored at -80 C for up to 6 months after date of receipt. Thawed aliquots should be used immediately, as repeated freeze/thaw cycles might result in loss of activity.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors