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504528 NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem

504528
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Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₇BrN₃Na₄O₆P 459836-30-7

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      Description
      OverviewA potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078 µM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy.
      Catalogue Number504528
      Brand Family Calbiochem®
      SynonymsNMDA Antagonist VII, NVP-AAM077, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate, PEAQX tetrasodium hydrate
      References
      ReferencesFrizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022.
      Milton, A., et al. 2013. J. Neurosci. 33, 1109.
      Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263.
      Kocsis, B., et al. 2012. Sleep. 35, 1011.
      Product Information
      CAS number459836-30-7
      FormWhite solid
      Hill FormulaC₁₇H₁₇BrN₃Na₄O₆P
      Chemical formulaC₁₇H₁₇BrN₃Na₄O₆P
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>0.015 and 0.078 µM for NR2A and NR2B, respectively.
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NVP-AAM077 Tetrasodium Hydrate - CAS 459836-30-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Frizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022.
      Milton, A., et al. 2013. J. Neurosci. 33, 1109.
      Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263.
      Kocsis, B., et al. 2012. Sleep. 35, 1011.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-March-2015 JSW
      SynonymsNMDA Antagonist VII, NVP-AAM077, [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium hydrate, PEAQX tetrasodium hydrate
      DescriptionA potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078 µM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy.
      FormWhite solid
      CAS number459836-30-7
      Chemical formulaC₁₇H₁₇BrN₃Na₄O₆P
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (24 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFrizelle. P., et al. 2006. Mol. Pharmacol. 70, 1022.
      Milton, A., et al. 2013. J. Neurosci. 33, 1109.
      Kochlamazashvili, G., et al. 2012. J. Neurosci. 32, 2263.
      Kocsis, B., et al. 2012. Sleep. 35, 1011.