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505020 NS3763 - CAS 70553-45-6 - Calbiochem

NS3763 - CAS 70553-45-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Gluk5
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
70553-45-6C₂₂H₁₆N₂O₆
Description
OverviewA potent non-competitive antagonist highly selective for homomeric GluK5 subtype of kainate receptors (IC50 = 1.6 µM) over homomeric GLUK6 receptors (IC50 > 30 µM). Negligible effect on native AMPA and NMDA receptors (IC50 > 30 µM). Used for assessing functional roles of GluK5 subtype of kainate receptors in ischemic brain injury, anxiety and stress-related disorders, and synaptic neurotransmissions.
Catalogue Number505020
Brand Family Calbiochem®
References
ReferencesHarvey, H., et al. 2012. Pharmacol. Biochem. & Beh. 100, 775.
Chamberlain, L., 2012. Hippocampus. 22, 555.
Matute, C., 2011. CNS Neurosci. & Ther. 17, 661.
Xu, J., et al. 2008. J. Biol. Chem. 283, 29355.
Christensen, J.K., et al. 2004. J. Pharmacol. & Exp. Ther. 309, 1003.
Product Information
CAS number 70553-45-6
FormOff-white solid
Hill FormulaC₂₂H₁₆N₂O₆
Chemical formulaC₂₂H₁₆N₂O₆
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetGluk5
Primary Target IC<sub>50</sub>1.6 →M
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
505020

Documentation

NS3763 - CAS 70553-45-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Harvey, H., et al. 2012. Pharmacol. Biochem. & Beh. 100, 775.
Chamberlain, L., 2012. Hippocampus. 22, 555.
Matute, C., 2011. CNS Neurosci. & Ther. 17, 661.
Xu, J., et al. 2008. J. Biol. Chem. 283, 29355.
Christensen, J.K., et al. 2004. J. Pharmacol. & Exp. Ther. 309, 1003.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2013 JSW
DescriptionA potent non-competitive antagonist highly selective for homomeric GluK5 subtype of kainate receptors (IC50 = 1.6 µM) over homomeric GLUK6 receptors (IC50 > 30 µM). Negligible effect on native AMPA and NMDA receptors (IC50 > 30 µM). Used for assessing functional roles of GluK5 subtype of kainate receptors in ischemic brain injury, anxiety and stress-related disorders, and synaptic neurotransmissions.
FormOff-white solid
CAS number 70553-45-6
Chemical formulaC₂₂H₁₆N₂O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHarvey, H., et al. 2012. Pharmacol. Biochem. & Beh. 100, 775.
Chamberlain, L., 2012. Hippocampus. 22, 555.
Matute, C., 2011. CNS Neurosci. & Ther. 17, 661.
Xu, J., et al. 2008. J. Biol. Chem. 283, 29355.
Christensen, J.K., et al. 2004. J. Pharmacol. & Exp. Ther. 309, 1003.