Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

500526 NOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
727664-79-1C₁₄H₁₀FNOS

Products

Catalog NumberPackaging Qty/Pack
5.00526.0001 Glass bottle 25 mg
Description
OverviewA cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phox bis-SH3 binding (IC50 = 4 vs. 0.3 µM) and NOX2 activity (IC50 = 4 vs. 0.6 µM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 µM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number500526
Brand Family Calbiochem®
Synonyms6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one, NADPH Oxidase Inhibitor VII
References
ReferencesSmith, S.M.E., et al. 2012. Chem. Biol. 19, 752.
Product Information
CAS number727664-79-1
FormLight brown powder
Hill FormulaC₁₄H₁₀FNOS
Chemical formulaC₁₄H₁₀FNOS
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.00526.0001 04055977244892

Documentation

NOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NOX Inhibitor VII, Thr101 - CAS 727664-79-1 - Calbiochem Certificates of Analysis

TitleLot Number
500526

References

Reference overview
Smith, S.M.E., et al. 2012. Chem. Biol. 19, 752.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-October-2013 JSW
Synonyms6-Fluoro-2-o-tolylbenzo[d]isothiazol-3(2H)-one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one, NADPH Oxidase Inhibitor VII
DescriptionA cell-permeable, selenium-to-sulfur substituted Ebselen (Cat. No. 324483) derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phox bis-SH3 binding (IC50 = 4 vs. 0.3 µM) and NOX2 activity (IC50 = 4 vs. 0.6 µM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7 µM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity.
FormLight brown powder
Intert gas (Yes/No) Packaged under inert gas
CAS number727664-79-1
Chemical formulaC₁₄H₁₀FNOS
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSmith, S.M.E., et al. 2012. Chem. Biol. 19, 752.