01-125 NGF 2.5S Protein, mouse

01-125
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSource
      CULT Mouse Male mouse submaxillary glands
      Description
      Catalogue Number01-125
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionNGF 2.5S Protein, mouse
      References
      Product Information
      PresentationLyophilized.
      Quality LevelMQ100
      Applications
      ApplicationThe mouse NGF 2.5S Protein( or nerve growth factor 2.5S) is available in a 100 µg format.
      Key Applications
      • Cell Culture
      Biological Information
      SourceMale mouse submaxillary glands
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
      Gene Symbol
      • NTF3
      • NT3
      • NGF2
      • HDNF
      • MGC129711
      • NGF-2
      • NT-3
      Purification MethodSterilized through a 0.2 micron membrane filter
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20783 # Seems to promotes the survival of visceral and proprioceptive sensory neurons.
      SIZE: 257 amino acids; 29355 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Brain and peripheral tissues.
      SIMILARITY: SwissProt: P20783 ## Belongs to the NGF-beta family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in a biological activity assay.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NGF 2.5S Protein, mouse Certificates of Analysis

      TitleLot Number
      NGF 2.5S, Mouse - 31789373178937
      NGF 2.5S, mouse3076740
      NGF 2.5S, mouse2929342
      NGF 2.5S, mouse2955422
      NGF 2.5S, mouse - 21482342148234
      NGF 2.5S, mouse - 23877192387719
      NGF 2.5S, mouse - 24246132424613
      NGF 2.5S, mouse - 13502741350274
      NGF 2.5S, mouse - 1617516175
      NGF 2.5S, mouse - 1770917709

      References

      Reference overviewApplicationPub Med ID
      Uptake of the dopaminergic neurotoxin, norsalsolinol, into PC12 cells via dopamine transporter.
      Maruyama, Y, et al.
      Arch. Toxicol., 75: 209-13 (2001)  2001

      Show Abstract
      Cell Stimulation11482518 11482518
      Expression of functional TrkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells.
      Tam, S Y, et al.
      Blood, 90: 1807-20 (1997)  1997

      Show Abstract
      Cell Culture9292513 9292513
      Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways.
      Párrizas, M, et al.
      J. Biol. Chem., 272: 154-61 (1997)  1997

      Show Abstract
      Apoptosis Induction8995241 8995241
      Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes.
      Lockhart, S T, et al.
      J. Neurosci., 17: 9573-82 (1997)  1997

      Show Abstract
      Cell Culture9391012 9391012
      Differential utilization of Trk autophosphorylation sites.
      Segal, R A, et al.
      J. Biol. Chem., 271: 20175-81 (1996)  1996

      Show Abstract
      Cell Stimulation8702742 8702742
      Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B.
      Rizzo, C, et al.
      J. Biol. Chem., 271: 29497-501 (1996)  1996

      Show Abstract
      Cell Culture8910618 8910618
      Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.
      Kamata, H, et al.
      J. Biol. Chem., 271: 33018-25 (1996)  1996

      Show Abstract
      Cell Stimulation8955147 8955147
      Plasmalopsychosine of human brain mimics the effect of nerve growth factor by activating its receptor kinase and mitogen-activated protein kinase in PC12 cells. Induction of neurite outgrowth and prevention of apoptosis.
      Sakakura, C, et al.
      J. Biol. Chem., 271: 946-52 (1996)  1996

      Show Abstract
      8557709 8557709
      Nerve growth factor revisited.
      Bradshaw, R A, et al.
      Trends Biochem. Sci., 18: 48-52 (1993)  1993

      8488558 8488558
      The nerve growth factor thirty-five years later.
      Levi-Montalcini, R
      In Vitro Cell. Dev. Biol., 23: 227-38 (1987)  1987

      3553145 3553145

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      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors