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480420 NF449 - CAS 389142-38-5 - Calbiochem

480420
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Empirical FormulaCAS #
C₄₁H₂₄N₆O₂₉S₈ · 8Na 389142-38-5

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      Description
      OverviewA potent Gsα-subunit-selective G-protein antagonist. Suppresses the rate of GTPγS binding to Gsα-s-subunit (IC50 = 140 nM) but not to Giα-1-subunit. Inhibits stimulation of adenylate cyclase activity in S49 cyc- cells (which lack endogenous Gsα-subunit) by exogenously added Gsα-subunit. Also blocks the coupling of β-adrenergic receptors to Gs (EC50 = 7.9 µM).
      Catalogue Number480420
      Brand Family Calbiochem®
      Synonyms4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)
      References
      ReferencesHulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
      Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
      Product Information
      CAS number389142-38-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
      Chemical formulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNF449, CAS 627034-85-9, is a potent Gsα-subunit-selective G-protein antagonist. Suppresses GTPγS binding to Gsα-s-subunit (IC50 = 140 nM). A highly potent P2X1 receptor antagonist (IC50 = 280 pM).
      Biological Information
      Primary TargetGsα-subunit-selective G-protein antagonist
      Primary Target IC<sub>50</sub>140 nM suppressing the rate of GTPγS binding to Gsα-s-subunit
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NF449 - CAS 389142-38-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NF449 - CAS 389142-38-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      480420

      References

      Reference overview
      Hulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
      Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms4,4ʹ,4ʹʹ,4ʹʹʹ-[Carbonyl-bis[imino-5,1,3-benzenetriyl bis-(carbonylimino)]]tetrakis-(benzene-1,3-disulfonic Acid, 8Na)
      DescriptionA potent G-selective G-protein antagonist. Suppresses the rate of GTPγS binding to Gsα-s (IC50 = 140 nM) but not in Giα-1. Inhibits stimulation of adenylate cyclase activity in S49 cyc cells (which lack endogenous G) by exogenously added Gsα-s. Also blocks the coupling of β-adrenergic receptors to Gs (EC50 = 7.9 µM). Acts as a reversible competitive antagonist of the human P2X receptor, exhibiting much higher potency at human P2X(1) than at P2X(7) receptors (IC50 = 50 nM vs 40 µM respectively).
      FormWhite solid
      CAS number389142-38-5
      Chemical formulaC₄₁H₂₄N₆O₂₉S₈ · 8Na
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilitydH₂O (100 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHulsmann, M., et al. 2003. Eur. J. Pharmacol. 470, 1.
      Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.