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481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

481480
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

Pricing & Availability

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481480-1MG
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      Plastic ampoule 1 mg
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      481480-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
          Catalogue Number481480
          Brand Family Calbiochem®
          SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
          References
          ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targettranslocation of the NF-κB active complex into the nucleus
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide ContentY
          Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem Certificates of Analysis

          TitleLot Number
          481480

          References

          Reference overview
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

          Brochure

          Title
          Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)

          Citations

          Title
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-March-2008 JSW
          SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
          DescriptionContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
          Purity≥97% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Citation
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.