GF012 Monocyte Chemotactic Protein-1, Recombinant human

GF012
20 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Human E.coli Greater than 99% by SDS-PAGE and HPLC analysis
      Description
      Catalogue NumberGF012
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMonocyte Chemotactic Protein-1, Recombinant human
      OverviewHuman macrophage chemoattractant protein-1 (MCP-1) also called human macrophage/monocyte chemotactic and activating factor (MCAF) is an 8.6 kDA protein containing 76 amino acids residues. It plays an important role in the inflammatory response of blood monocytes and tissue macrophages.
      Alternate Names
      • MCP-1
      • MCAF
      References
      Product Information
      PresentationLyophilized protein with no additives.
      Quality LevelMQ100
      Applications
      ApplicationThe human macrophage chemoattractant protein-1 (or MCP-1 protein) also called human macrophage/monocyte chemotactic & activating factor (MCAF) is an 8.6 kDA protein containing 76 amino acids residues.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 99% by SDS-PAGE and HPLC analysis
      SourceE.coli
      Specific ActivityThe biological activity was determined by a chemotaxis assay using human monocytes. Significant chemotaxis response was found to be in the range of 10-100 ng/mL.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
      Gene Symbol
      • CCL2
      • SMC-CF
      • MCAF
      • HSMCR30
      • GDCF-2
      • SCYA2
      • MCP1
      • HC11
      • MGC9434
      • MCP-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P13500 # Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
      SIZE: 99 amino acids; 11025 Da
      SUBUNIT: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.
      SUBCELLULAR LOCATION: Secreted.
      PTM: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
      SIMILARITY: SwissProt: P13500 ## Belongs to the intercrine beta (chemokine CC) family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in water to a concentration of 0.1 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted GF012 should be stored at -20°C in undiluted aliquots for up to six months.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Monocyte Chemotactic Protein-1, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Monocyte Chemotactic Protein-1, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)2911589
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)3035210
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)2831356
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)2477823
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)2975904
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)2867537
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)2944647
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF) - 23677892367789
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF) - 20427022042702
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF) - 21932782193278

      Data Sheet

      Title
      RECOMBINANT HUMAN MCP-1 (HUMAN MCAF)

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors