531206 Mnk2 Inhibitor IV - Calbiochem

531206
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₈N₄O₃S

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM. Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531206
      Brand Family Calbiochem®
      SynonymsMitogen-activated protein kinase-interacting kinase 2
      References
      ReferencesDiab, S., et al. 2014. ChemMedChem. 9, 962.
      Product Information
      FormYellow powder
      Hill FormulaC₁₇H₁₈N₄O₃S
      Chemical formulaC₁₇H₁₈N₄O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMnk2
      Primary Target K<sub>i</sub>370 nM
      Purity>98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Mnk2 Inhibitor IV - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Diab, S., et al. 2014. ChemMedChem. 9, 962.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-December-2014 JSW
      SynonymsMitogen-activated protein kinase-interacting kinase 2
      DescriptionA cell permeable phenylaminopyrimidine derived compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 2 (Mnk2, Ki = 370 nM in MV4-11 cells). Displays high selectivity over CDK2 (Ki >10 µM) and CDK9 (Ki = 1.66 µM). Shown to block the phosphorylation of elF4E in and effectively inhibit the proliferation of MV4-11 cells (GI50 = 780 nM) by inducing a cell cycle arrest at G0/G1 phase. Diminishes the expression of Mcl-1 and causes PARP cleavage in A2780 ovarian cancer cells.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₈N₄O₃S
      Purity>98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDiab, S., et al. 2014. ChemMedChem. 9, 962.