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475870 MnTBAP - Calbiochem

475870
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Key Specifications Table

Empirical FormulaCAS #
C₄₈H₂₈ClMnN₄O₈ 55266-18-7

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475870-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewCell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
      Catalogue Number475870
      Brand Family Calbiochem®
      SynonymsMn(III)tetrakis(4-benzoic acid)porphyrin Chloride
      References
      ReferencesAladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
      Szabo, C., et al. 1996. FEBS Lett. 381, 82.
      Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
      Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
      Product Information
      CAS number55266-18-7
      ATP CompetitiveN
      FormBrown solid
      Hill FormulaC₄₈H₂₈ClMnN₄O₈
      Chemical formulaC₄₈H₂₈ClMnN₄O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMnTBAP, CAS 55266-18-7, is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
      Biological Information
      Primary TargetSuperoxide dismutase (SOD) mimetic
      Primary Target IC<sub>50</sub>EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MnTBAP - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MnTBAP - Calbiochem Certificates of Analysis

      TitleLot Number
      475870

      References

      Reference overview
      Aladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
      Szabo, C., et al. 1996. FEBS Lett. 381, 82.
      Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
      Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress (EMD)

      Citations

      Title
    • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsMn(III)tetrakis(4-benzoic acid)porphyrin Chloride
      DescriptionCell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).
      FormBrown solid
      CAS number55266-18-7
      Chemical formulaC₄₈H₂₈ClMnN₄O₈
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityAqueous alkaline solution
      Storage -20°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
      Szabo, C., et al. 1996. FEBS Lett. 381, 82.
      Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
      Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
      Citation
    • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.