504817 Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem

504817
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₂N₂O₂ 56396-35-1

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      Glass bottle 5 mg
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      5.04817.0002
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          Description
          OverviewA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
          Catalogue Number504817
          Brand Family Calbiochem®
          Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
          References
          ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
          Bricker, D.K., et al. 2012. Science 337, 96.
          Herzig, S., et al. 2012. Science 337, 93.
          Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
          Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
          Halestrap, A.P. 1978. Biochem. J. 172, 377.
          Halestrap, A.P. 1975. Biochem. J. 145, 85.
          Product Information
          CAS number56396-35-1
          FormBright yellow solid
          Hill FormulaC₁₈H₁₂N₂O₂
          Chemical formulaC₁₈H₁₂N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetmitochondria
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Mitochondrial Pyruvate Carrier Inhibitor, UK5099 - CAS 56396-35-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Divakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
          Bricker, D.K., et al. 2012. Science 337, 96.
          Herzig, S., et al. 2012. Science 337, 93.
          Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
          Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
          Halestrap, A.P. 1978. Biochem. J. 172, 377.
          Halestrap, A.P. 1975. Biochem. J. 145, 85.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms(E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023
          DescriptionA cell-permeable α-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50 nM in rat heart mitochondria; Ki ≤ 1 µM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2 µM in human myocytes and skeletal muscle myotubes).
          FormBright yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number56396-35-1
          Chemical formulaC₁₈H₁₂N₂O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for up to 2 weeks at -20°C or for up to 6 weeks at -70°C.
          Toxicity Standard Handling
          ReferencesDivakaruni, A.S., et al. 2013. Proc. Natl. acad. Sci. USA 110, 5422.
          Bricker, D.K., et al. 2012. Science 337, 96.
          Herzig, S., et al. 2012. Science 337, 93.
          Hinoi, E., et al. 2006. Mol. Pharmacol. 70, 925.
          Hildyard, J.C.W., et al. 2005. Biochim. Biophys. Acta 1707, 221.
          Halestrap, A.P. 1978. Biochem. J. 172, 377.
          Halestrap, A.P. 1975. Biochem. J. 145, 85.