|Application||The Millicell-ERS (Electrical Resistance System) reliably measures membrane potential & resistance of epithelial cells in culture.|
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|Safety Information according to GHS|
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Millicell ERS-2 Voltohmmeter SDS
|Reference overview||Pub Med ID|
|Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion.|
Hoy, Benjamin, et al.
EMBO Rep., 11: 798-804 (2010) 2010
Mammalian and prokaryotic high-temperature requirement A (HtrA) proteins are chaperones and serine proteases with important roles in protein quality control. Here, we describe an entirely new function of HtrA and identify it as a new secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of the cell-adhesion protein E-cadherin. E-cadherin shedding disrupts epithelial barrier functions allowing H. pylori designed to access the intercellular space. We then designed a small-molecule inhibitor that efficiently blocks HtrA activity, E-cadherin cleavage and intercellular entry of H. pylori.