|Detecting Low Concentrations of Microbiological Contamination in Pharmaceutical Grade Water Using Millipore’s MicropreSure On-line Filtration Samplers, MSOPENR 01, MSHA WGS 48, AN0002EN00|
|MicropreSure On-Line Filtration Samplers|
|MicropreSure On-Line Filtration Samplers: Ready-to-use devices sample and test in-process bottled water|
Validation engineers and Quality Control specialists regularly sample the drops and tanks of process water loops to ensure low bacterial levels and to identify bio-contamination problems early. Traditional multi-step sampling methods are often inconvenient and a potential problem for time-pressed personnel. The routine of setting up lab equipment and processing samples can be rushed, sometimes at the expense of proper aseptic procedures.
By reducing the sampling process to a few simple steps performed within a closed system, the MicropreSure on-line filtration sampler improves microbiological testing of purified water at the point-of-use. This on-line filtration sampler complies with USP/EP guidelines.
Closed Design for Accurate Sampling
The simple, protective design of the MicropreSure sampler provides dependable microbiological sampling and reduces contamination risk in any environment. Organisms are captured on the membrane right at the collection site, providing a representative sample for accurate enumeration. The filtration chamber remains closed during all stages of sampling, so operator skill and environmental control are less critical.
Fast and Reliable In-Process Collection
The MicropreSure sampler and monitor saves steps and speeds collection - providing an easy method to secure the samples you need for tracking and trending process water purity. It uses the pressure in tanks or pressurized lines to process and collect samples through a microporous membrane within an enclosed chamber.
And because the MicropreSure devices are securely locked together, sampling pressurized water lines will not create water leaks.
Sampling and Filtration in One Step
MicropreSure samplers and monitors are sterile and ready to use. With MicropreSure on-line filtration samplers, you sample and process in one step, eliminating the need to sterilize sample containers or transport them back to the laboratory. After processing, microbes are contained and protected within the lightweight MicropreSure devices that are easily carried.
Tests Larger Volumes or During an Extended Period of Time
During validation, a 100 mL sample may not reveal low level microbial contaminants in a water sample. The MicropreSure sampler and monitor allows for processing liters of water through its enclosed housing. In addition, the strong fit between the Luer fitting and the sanitary sampling valve means you can continuously sample over an extended period of time. Results can then reflect build-up contamination over a batch, a shift, or a day.
Convenient In-Process Microbiological Analysis
The MicropreSure sampler and monitor are innovative and convenient tools that allow water samples to be aseptically processed, right at the collection site. The membrane, enclosed in its own housing, is protected until it is ready to be processed in the laboratory.
MicropreSure On-Line Filtration Samplers and Monitors Improve Traditional Multiple-step Sampling Methods:
- No assembly
- No sterilization
- No sample containers to transport
- No risk of external contamination
Identifying the Sampling Port Outlet and Choosing the Valve Adapter
If the sampling port outlet is a male Luer port, use the MicropreSure on-line filtration sampler without a valve outlet adapter.
Otherwise, install a MicropreSure sanitary sampling valve, or install a valve outlet adapter.
|Materials of Construction|
|Filtration Chamber/Base||Polycarbonate (PC)|
|Membrane||Mixed Cellulose Esters (MCE)|
|Filter Support||High density polyethylene|
|Device Height, mm||45|
|Filter Diameter||47 mm|
|Pore Size||0.45 µm|
|Filtration Area||9.1 cm²|
|at 25 °C||3 bar|
|at 90 °C||1 bar|
|Temperatute Range, °C||5 – 90|