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506419 Methysergide Maleate - CAS 129-49-7 - Calbiochem

506419
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₂₇N₃O₂·C₄H₄O₄ 129-49-7

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      Description
      OverviewAn antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
      Catalogue Number506419
      Brand Family Calbiochem®
      Synonyms5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
      References
      ReferencesMatsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
      IUHPAR Database 2013.
      Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
      Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
      Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.
      Product Information
      CAS number129-49-7
      FormOff-white solid
      Hill FormulaC₂₁H₂₇N₃O₂·C₄H₄O₄
      Chemical formulaC₂₁H₂₇N₃O₂·C₄H₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 36/37/39-46

      Wear suitable protective clothing, gloves and eye/face protection.
      If swallowed, seek medical advice immediately and show this container or label.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Methysergide Maleate - CAS 129-49-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Matsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
      IUHPAR Database 2013.
      Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
      Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
      Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-October-2013 JSW
      Synonyms5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
      DescriptionAn antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
      FormOff-white solid
      CAS number129-49-7
      Chemical formulaC₂₁H₂₇N₃O₂·C₄H₄O₄
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (10 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesMatsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
      IUHPAR Database 2013.
      Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
      Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
      Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.