Millipore Sigma Vibrant Logo
Attention: We have moved. EMD Millipore products are no longer available for purchase on emdmillipore.com.Learn More

504905 Memantine Hydrochloride - CAS 41100-52-1 - Calbiochem

Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,5-Dimethyl-1-adamantanamine hydrochloride

Primary Target: NMDA receptors
View Products on Sigmaaldrich.com
504905
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
41100-52-1C₁₂H₂₁N•HCl

Products

Catalog NumberPackaging Qty/Pack
5.04905.0001 Glass bottle 50 mg
Description
OverviewA very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
Catalogue Number504905
Brand Family Calbiochem®
Synonyms3,5-Dimethyl-1-adamantanamine hydrochloride
References
ReferencesLimapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
Anand, A., et al. 2012. Bipolar Dis. 14, 64.
Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
Lee, G., et al. 2012. Psychiatry Investig. 9, 166.
Product Information
CAS number41100-52-1
FormWhite solid
Hill FormulaC₁₂H₂₁N•HCl
Chemical formulaC₁₂H₂₁N•HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNMDA receptors
Primary Target IC<sub>50</sub>0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.04905.0001 04055977263633

Documentation

Memantine Hydrochloride - CAS 41100-52-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Limapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
Anand, A., et al. 2012. Bipolar Dis. 14, 64.
Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
Lee, G., et al. 2012. Psychiatry Investig. 9, 166.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2013 JSW
Synonyms3,5-Dimethyl-1-adamantanamine hydrochloride
DescriptionA very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
FormWhite solid
CAS number41100-52-1
Chemical formulaC₁₂H₂₁N•HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLimapichat, W., et al. 2012. ACS Chem. Neurosci. 4, 255.
Anand, A., et al. 2012. Bipolar Dis. 14, 64.
Lopes, P., et al. 2013. Brain and Behavior. 3, 67.
Howard, R., et al. 2012. New Eng. J. Med. 366, 893.
Parsons, G., et al. 1999. Neuropharmacol. 38, 735.
Lee, G., et al. 2012. Psychiatry Investig. 9, 166.