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531976 MPS1 Inhibitor III, AZ3146 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₄H₃₂N₆O₃

Products

Catalog NumberPackaging Qty/Pack
5.31976.0001 Glass bottle 10 mg
Description
OverviewA cell permeable purinone derivative that acts as a highly potent and selective inhibitor of monopolar spindle 1 kinase (MPS1; IC50 = ~35 nM). Inhibits the phosphorylation of full-length immunoprecipitated human MPS1 and exhibits minimal activity against a panel of 49 other protein kinases. Has much reduced activity against FAK, JNK1, JNK2, and KIT and does not affect the activity of mitotic-specific phosphoforms of Aurora B and BubR1. Induces a significant reduction in time to complete mitosis (from 90 min to 32 min) and causes abnormal mitosis where over 50% of cells enter anaphase without aligning their chromosomes.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number531976
Brand Family Calbiochem®
SynonymsAZ 3146, AZ-3146, Monopolar Spindle 1 Kinase Inhibitor, AZ3146
References
ReferencesHewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.
Product Information
FormPurple powder
Hill FormulaC₂₄H₃₂N₆O₃
Chemical formulaC₂₄H₃₂N₆O₃
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetMPS1
Primary Target IC<sub>50</sub>~35 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.31976.0001 04055977260021

Documentation

MPS1 Inhibitor III, AZ3146 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Hewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-December-2014 JSW
SynonymsAZ 3146, AZ-3146, Monopolar Spindle 1 Kinase Inhibitor, AZ3146
DescriptionA cell permeable purinone derivative that acts as a highly potent and selective inhibitor of monopolar spindle 1 kinase (MPS1; IC50 = ~35 nM). Inhibits the phosphorylation of full-length immunoprecipitated human MPS1 and exhibits minimal activity against a panel of 49 other protein kinases. Has much reduced activity against FAK, JNK1, JNK2, and KIT and does not affect the activity of mitotic-specific phosphoforms of Aurora B and BubR1. Induces a significant reduction in time to complete mitosis (from 90 min to 32 min) and causes abnormal mitosis where over 50% of cells enter anaphase without aligning their chromosomes.
FormPurple powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₄H₃₂N₆O₃
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHewitt, L., et al. 2010. Jour. Cell Biol. 190, 25.