534352 MNK Inhibitor IV, Mnk-I1 - Calbiochem

534352
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₂₇F₂N₅O₂S

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable thieno[2,3-d]pyrimidine compound that acts as a selective inhibitor of MAP kinase-interacting kinases 1 and 2 (Mnk1 and 2: IC50 = 23 and 16 nM for MNK1 and MNK2, respectively). Displays much reduced activity against several other protein kinases and does not affect the phosphorylation of ERK, Akt, mTORC1, and ribosomal S6 kinase. Shown to strongly inhibit eIF4E phosphorylation (~1 µM) and abolished the activity completely at higher concentration in MDA-MB-231 and SSC25 cancer cell (~ 1 µM). Shown to be much more effective Mnk inhibitor than CGP57380 (Cat. No. 454861). Reported to inhibit the migration of mouse embryonic fibroblasts and MDA-MB-231 and SCC25 cells, but does not affect their viability and proliferation.
      Catalogue Number534352
      Brand Family Calbiochem®
      SynonymsMNK1 Inhibitor, Mnk-I1
      References
      ReferencesBeggs, J.E., et al. 2015. Biochem. J. 467, 63.
      Product Information
      FormLight beige solid
      Hill FormulaC₂₂H₂₇F₂N₅O₂S
      Chemical formulaC₂₂H₂₇F₂N₅O₂S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMNK
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MNK Inhibitor IV, Mnk-I1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Beggs, J.E., et al. 2015. Biochem. J. 467, 63.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-July-2017 JSW
      SynonymsMNK1 Inhibitor, Mnk-I1
      DescriptionA cell-permeable thieno[2,3-d]pyrimidine compound that acts as a selective inhibitor of MAP kinase-interacting kinases 1 and 2 (Mnk1 and 2: IC50 = 23 and 16 nM for MNK1 and MNK2, respectively). Displays much reduced activity against several other protein kinases and does not affect the phosphorylation of ERK, Akt, mTORC1, and ribosomal S6 kinase. Shown to strongly inhibit eIF4E phosphorylation (~1 µM) and abolished the activity completely at higher concentration in MDA-MB-231 and SSC25 cancer cell (~ 1 µM). Shown to be much more effective Mnk inhibitor than CGP57380 (Cat. No. 454861). Reported to inhibit the migration of mouse embryonic fibroblasts and MDA-MB-231 and SCC25 cells, but does not affect their viability and proliferation.
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₂₇F₂N₅O₂S
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBeggs, J.E., et al. 2015. Biochem. J. 467, 63.