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444284 MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

444284
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₈BrNO₄S 199850-67-4

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444284-5MG
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      Description
      OverviewA cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
      Catalogue Number444284
      Brand Family Calbiochem®
      Synonyms(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
      References
      ReferencesPaolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
      Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
      Peterson, J.T., et al. 2001. Circulation 103, 2303.
      Spinale, F.G., et al. 1999. Circ. Res. 85, 364.
      Product Information
      CAS number199850-67-4
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₇H₁₈BrNO₄S
      Chemical formulaC₁₇H₁₈BrNO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-2, -3, and -13
      Primary Target IC<sub>50</sub>47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      444284

      References

      Reference overview
      Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
      Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
      Peterson, J.T., et al. 2001. Circulation 103, 2303.
      Spinale, F.G., et al. 1999. Circ. Res. 85, 364.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      Synonyms(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
      DescriptionA cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
      FormOff-white solid
      CAS number199850-67-4
      Chemical formulaC₁₇H₁₈BrNO₄S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (40 mg/ml) or Ethanol (40 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesPaolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
      Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
      Peterson, J.T., et al. 2001. Circulation 103, 2303.
      Spinale, F.G., et al. 1999. Circ. Res. 85, 364.