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444283 MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem

444283
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₂₂H₂₀F₂N₄O₂ 544678-85-5

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444283-1MG
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      Description
      OverviewA pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
      Catalogue Number444283
      Brand Family Calbiochem®
      SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
      References
      ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.
      Product Information
      CAS number544678-85-5
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₂₂H₂₀F₂N₄O₂
      Chemical formulaC₂₂H₂₀F₂N₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-13 activity
      Primary Target IC<sub>50</sub>8 nM against MMP-13
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      444283

      References

      Reference overview
      Engel, C.K., et al. 2005. Chem. Biol. 12, 181.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
      DescriptionA potent inhibitor of MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number544678-85-5
      Chemical formulaC₂₂H₂₀F₂N₄O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Further dilute in buffer immediately prior to use.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.