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444965 MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem

The MEK1/2 Inhibitor II, also referenced under CAS 212631-61-3, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide

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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
212631-61-3C₁₈H₁₆F₃IN₂O₂

Products

Catalog NumberPackaging Qty/Pack
444965-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
Catalogue Number444965
Brand Family Calbiochem®
SynonymsN-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
References
ReferencesPelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.
Product Information
CAS number212631-61-3
FormWhite solid
Hill FormulaC₁₈H₁₆F₃IN₂O₂
Chemical formulaC₁₈H₁₆F₃IN₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
444965-5MG4055977204513

Documentation

MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MEK Inhibitor VIII - CAS 212631-61-3 - Calbiochem Certificates of Analysis

TitleLot Number
444965

References

Reference overview
Pelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-08 RFH
SynonymsN-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
DescriptionA cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number212631-61-3
Chemical formulaC₁₈H₁₆F₃IN₂O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (45 mg/ml) or Ethanol (45 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPelletier, J.P., et al. 2003. Arthritis Rheum. 48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol. 138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm. 236, 135.