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444145 MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

The MDM2 Inhibitor, also referenced under CAS 562823-84-1, controls the biological activity of MDM2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV

Primary Target: MDM2
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
562823-84-1C₁₅H₁₂BIO₃

Products

Catalog NumberPackaging Qty/Pack
444145-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable boranyl-chalcone that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex. Exhibits selective toxicity towards MDM2 overexpressing human breast cancer cell lines (IC50 = 10, 8.8, and 7 µM for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively) compared to normal breast cell lines (IC50 = 75 and 63 µM for MCF-10A and MCF-12A, respectively).
Catalogue Number444145
Brand Family Calbiochem®
Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
References
ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.
Product Information
CAS number562823-84-1
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₅H₁₂BIO₃
Chemical formulaC₁₅H₁₂BIO₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMDM2
Primary Target IC<sub>50</sub>10, 8.8, and 7 µM in selective toxicity for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
444145-10MG4055977205459

Documentation

MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem Certificates of Analysis

TitleLot Number
444145

References

Reference overview
Kumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.

Brochure

Title
Interactive Pathway Calendar
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-February-2008 JSW
Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
DescriptionA cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 µM for MDA-MB-435, 8.8 µM for MDA-MB-231, and 7 µM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 µM for MCF-10A and 63 µM for MCF-12A).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number562823-84-1
Chemical formulaC₁₅H₁₂BIO₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.