444144 MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

444144
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₃H₂₀N₂O 6964-62-1

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444144-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
      Catalogue Number444144
      Brand Family Calbiochem®
      Synonyms7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
      References
      ReferencesLu, Y., et al. 2006. J. Med. Chem. 49, 3759.
      Product Information
      CAS number6964-62-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₂₀N₂O
      Chemical formulaC₂₃H₂₀N₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetMDM2
      Primary Target K<sub>i</sub>120 nM against MDM2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      444144

      References

      Reference overview
      Lu, Y., et al. 2006. J. Med. Chem. 49, 3759.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
      DescriptionA cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number6964-62-1
      Chemical formulaC₂₃H₂₀N₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesLu, Y., et al. 2006. J. Med. Chem. 49, 3759.