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508162 Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
34552-83-5C₂₉H₃₃ClN₂O₂·HCl

Products

Catalog NumberPackaging Qty/Pack
5.08162.0001 Glass bottle 1 gm
Description
OverviewA very potent and highly selective peripheral resctricted µ-opioid receptor agonist (Ki = 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.
Catalogue Number508162
Brand Family Calbiochem®
Synonymsµ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium
References
ReferencesCheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.
Product Information
CAS number34552-83-5
FormWhite solid
Hill FormulaC₂₉H₃₃ClN₂O₂·HCl
Chemical formulaC₂₉H₃₃ClN₂O₂·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetu opioid receptor
Primary Target K<sub>i</sub>2 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 25

Toxic if swallowed.
S PhraseS: 36/37/39-46

Wear suitable protective clothing, gloves and eye/face protection.
If swallowed, seek medical advice immediately and show this container or label.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.08162.0001 04055977261738

Documentation

Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem Certificates of Analysis

TitleLot Number
508162

References

Reference overview
Cheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2013 JSW
Synonymsµ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium
DescriptionA very potent and highly selective peripheral resctricted µ-opioid receptor agonist (Ki = 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.
FormWhite solid
CAS number34552-83-5
Chemical formulaC₂₉H₃₃ClN₂O₂·HCl
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mM) or Ethanol (50 mM). Warming is required for complete solubilization in ethanol.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesCheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.