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538769 Lipid Uptake Inhibitor, ML278 - Calbiochem

Lipid Uptake Inhibitor, ML278 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,5-Dimethoxy-N-(4-(1-(2-methoxyacetyl)indolin-5-yl)thiazol-2-yl)benzamide, SR-BI inhibitor ML278

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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₂₃N₃O₅S

Products

Catalog NumberPackaging Qty/Pack
5.38769.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC50 = 6 nM). Shown to block the uptake of [3H] labeled cholesteryl oleate ester ([3H]CE) from [3H]CE-HDL (IC50 = 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 µM). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538769
Brand Family Calbiochem®
Synonyms3,5-Dimethoxy-N-(4-(1-(2-methoxyacetyl)indolin-5-yl)thiazol-2-yl)benzamide, SR-BI inhibitor ML278
References
ReferencesDockendorff, C., et al. 2015. ACS Med. Chem. Lett. 6, 375.
Product Information
FormLight yellow solid
Hill FormulaC₂₃H₂₃N₃O₅S
Chemical formulaC₂₃H₂₃N₃O₅S
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetscavenger receptor class B type I
Primary Target IC<sub>50</sub>6 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Lipid Uptake Inhibitor, ML278 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Dockendorff, C., et al. 2015. ACS Med. Chem. Lett. 6, 375.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-March-2017 JSW
Synonyms3,5-Dimethoxy-N-(4-(1-(2-methoxyacetyl)indolin-5-yl)thiazol-2-yl)benzamide, SR-BI inhibitor ML278
DescriptionA cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI; IC50 = 6 nM). Shown to block the uptake of [3H] labeled cholesteryl oleate ester ([3H]CE) from [3H]CE-HDL (IC50 = 7 nM). Exhibits high selectivity when tested against a panel of 67 different receptors and secondary targets (at 10 µM). Displays excellent stability in human plasma (99% remaining after 5 h, with 94% plasma protein bound) and mouse liver microsomes (75% remaining after 1 h).
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₃H₂₃N₃O₅S
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDockendorff, C., et al. 2015. ACS Med. Chem. Lett. 6, 375.