108975 Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem

108975
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₂₀H₃₈N₆O₄ . 1/2H₂SO₄ 103476-89-7

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              108975-50MG
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                      Description
                      OverviewA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).
                      Catalogue Number108975
                      Brand Family Calbiochem®
                      SynonymsAc-LLR-CHO, ½H₂SO₄
                      References
                      ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                      Sarin, A., et al. 1994. J. Immunol. 153, 862.
                      Product Information
                      CAS number103476-89-7
                      ATP CompetitiveN
                      FormWhite lyophilized solid
                      Hill FormulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                      Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                      Hygroscopic Hygroscopic
                      ReversibleY
                      Structure formula ImageStructure formula Image
                      Quality LevelMQ200
                      Applications
                      Biological Information
                      Primary Targettrypsin- and cysteine-like proteases
                      Purity≥90% by HPLC
                      Physicochemical Information
                      Cell permeableN
                      Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
                      Dimensions
                      Materials Information
                      Toxicological Information
                      Safety Information according to GHS
                      Safety Information
                      Product Usage Statements
                      Storage and Shipping Information
                      Ship Code Ambient Temperature Only
                      Toxicity Standard Handling
                      Storage -20°C
                      Hygroscopic Hygroscopic
                      Do not freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
                      Packaging Information
                      Transport Information
                      Supplemental Information
                      Specifications

                      Documentation

                      Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem SDS

                      Title

                      Safety Data Sheet (SDS) 

                      Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem Certificates of Analysis

                      TitleLot Number
                      108975

                      References

                      Reference overview
                      Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                      Sarin, A., et al. 1994. J. Immunol. 153, 862.

                      Citations

                      Title
                    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
                    • Data Sheet

                      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                      Revision29-March-2010 JSW
                      SynonymsAc-LLR-CHO, ½H₂SO₄
                      DescriptionA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
                      FormWhite lyophilized solid
                      CAS number103476-89-7
                      Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
                      Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
                      Structure formulaStructure formula
                      Purity≥90% by HPLC
                      SolubilityH₂O (50 mg/ml)
                      Storage -20°C
                      Hygroscopic
                      Do Not Freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
                      Toxicity Standard Handling
                      Merck USA index14, 5456
                      ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
                      Sarin, A., et al. 1994. J. Immunol. 153, 862.
                      Citation
                    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.