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504658 LY 367385 Hydrochloride - CAS 198419-91-9 (fr - Calbiochem

504658
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Key Specifications Table

Empirical FormulaCAS #
C₁₀H₁₁NO₄•HCl 198419-91-9

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      Glass bottle 5 mg
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      Description
      OverviewA potent antagonist selective for mGlu1a receptors (IC50 = 8.8 µM and >100 µM for mGlu1a and mGlu5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu1a in various brain functions and disorders in which neural transmissions via mGlu1a receptors are involved.
      Catalogue Number504658
      Brand Family Calbiochem®
      Synonyms(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
      References
      ReferencesYoung, R., et al. 2013. J. Neurosci. 33, 2526.
      Chapman, A., et al. 1999. Eur. J. Pharmacol. 368, 17.
      Bruno, V., et al. 1999. Neuropharmacol. 38, 199.
      Clark, X., et al. 1997. Bioorg. Med. Chem. Lett. 7, 2777.
      Product Information
      CAS number198419-91-9
      FormWhite powder
      FormulationSupplied as a hydrochloride salt.
      Hill FormulaC₁₀H₁₁NO₄•HCl
      Chemical formulaC₁₀H₁₁NO₄•HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₁ receptors
      Primary Target IC<sub>50</sub>8.8 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      LY 367385 Hydrochloride - CAS 198419-91-9 (fr - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Young, R., et al. 2013. J. Neurosci. 33, 2526.
      Chapman, A., et al. 1999. Eur. J. Pharmacol. 368, 17.
      Bruno, V., et al. 1999. Neuropharmacol. 38, 199.
      Clark, X., et al. 1997. Bioorg. Med. Chem. Lett. 7, 2777.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
      DescriptionA potent antagonist selective for mGlu1a receptors (IC50 = 8.8 µM and >100 µM for mGlu1a and mGlu5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu1a in various brain functions and disorders in which neural transmissions via mGlu1a receptors are involved.
      FormWhite powder
      FormulationSupplied as a hydrochloride salt.
      CAS number198419-91-9
      Chemical formulaC₁₀H₁₁NO₄•HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (18 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYoung, R., et al. 2013. J. Neurosci. 33, 2526.
      Chapman, A., et al. 1999. Eur. J. Pharmacol. 368, 17.
      Bruno, V., et al. 1999. Neuropharmacol. 38, 199.
      Clark, X., et al. 1997. Bioorg. Med. Chem. Lett. 7, 2777.