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504658 LY 367385 Hydrochloride - CAS 198419-91-9 (fr - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid

Primary Target: mGlu₁ receptors
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
198419-91-9C₁₀H₁₁NO₄•HCl

Products

Catalog NumberPackaging Qty/Pack
5.04658.0001 Glass bottle 5 mg
Description
OverviewA potent antagonist selective for mGlu1a receptors (IC50 = 8.8 µM and >100 µM for mGlu1a and mGlu5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu1a in various brain functions and disorders in which neural transmissions via mGlu1a receptors are involved.
Catalogue Number504658
Brand Family Calbiochem®
Synonyms(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
References
ReferencesYoung, R., et al. 2013. J. Neurosci. 33, 2526.
Chapman, A., et al. 1999. Eur. J. Pharmacol. 368, 17.
Bruno, V., et al. 1999. Neuropharmacol. 38, 199.
Clark, X., et al. 1997. Bioorg. Med. Chem. Lett. 7, 2777.
Product Information
CAS number198419-91-9
FormWhite powder
FormulationSupplied as a hydrochloride salt.
Hill FormulaC₁₀H₁₁NO₄•HCl
Chemical formulaC₁₀H₁₁NO₄•HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetmGlu₁ receptors
Primary Target IC<sub>50</sub>8.8 µM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
5.04658.00014055977244014

Documentation

LY 367385 Hydrochloride - CAS 198419-91-9 (fr - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Young, R., et al. 2013. J. Neurosci. 33, 2526.
Chapman, A., et al. 1999. Eur. J. Pharmacol. 368, 17.
Bruno, V., et al. 1999. Neuropharmacol. 38, 199.
Clark, X., et al. 1997. Bioorg. Med. Chem. Lett. 7, 2777.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
Synonyms(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid
DescriptionA potent antagonist selective for mGlu1a receptors (IC50 = 8.8 µM and >100 µM for mGlu1a and mGlu5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu1a in various brain functions and disorders in which neural transmissions via mGlu1a receptors are involved.
FormWhite powder
FormulationSupplied as a hydrochloride salt.
CAS number198419-91-9
Chemical formulaC₁₀H₁₁NO₄•HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (18 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYoung, R., et al. 2013. J. Neurosci. 33, 2526.
Chapman, A., et al. 1999. Eur. J. Pharmacol. 368, 17.
Bruno, V., et al. 1999. Neuropharmacol. 38, 199.
Clark, X., et al. 1997. Bioorg. Med. Chem. Lett. 7, 2777.