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508150 LY 344864 Hydrochloride - CAS 186544-26-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864

Primary Target: 5-HT1F
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
186544-26-3C₂₁H₂₂FN₃O·HCl
Description
OverviewA selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)
Catalogue Number508150
Brand Family Calbiochem®
Synonyms5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
References
ReferencesAmrutkar, D. V. et al. 2012. Pain. 153, 830.
Phebus, L. A. et al. 1997. Life Sci. 61, 2117.
Product Information
CAS number186544-26-3
FormWhite solid
Hill FormulaC₂₁H₂₂FN₃O·HCl
Chemical formulaC₂₁H₂₂FN₃O·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT1F
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
508150

Documentation

LY 344864 Hydrochloride - CAS 186544-26-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Amrutkar, D. V. et al. 2012. Pain. 153, 830.
Phebus, L. A. et al. 1997. Life Sci. 61, 2117.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-October-2013 JSW
Synonyms5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
DescriptionA selective, brain penetrant, full agonist for the 5-HT1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT1B/1D antagonist GR 127935 (Cat. No. 508014)
FormWhite solid
CAS number186544-26-3
Chemical formulaC₂₁H₂₂FN₃O·HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM) or H₂O (10 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAmrutkar, D. V. et al. 2012. Pain. 153, 830.
Phebus, L. A. et al. 1997. Life Sci. 61, 2117.