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505880 L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
158985-00-3C₁₈H₁₉N₄Cl•3HCl

Products

Catalog NumberPackaging Qty/Pack
5.05880.0001 Glass bottle 10 mg
Description
OverviewSelective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
Catalogue Number505880
Brand Family Calbiochem®
SynonymsDopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
References
ReferencesLi, H. et al., 2013. J. Neurosci. 33, 3135.
Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.
Product Information
CAS number158985-00-3
FormOff-white solid
Hill FormulaC₁₈H₁₉N₄Cl•3HCl
Chemical formulaC₁₈H₁₉N₄Cl•3HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetD₄
Primary Target K<sub>i</sub>0.4 nM
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
5.05880.00014055977263169

Documentation

L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem Certificates of Analysis

TitleLot Number
505880

References

Reference overview
Li, H. et al., 2013. J. Neurosci. 33, 3135.
Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2013 JSW
SynonymsDopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
DescriptionSelective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
FormOff-white solid
CAS number158985-00-3
Chemical formulaC₁₈H₁₉N₄Cl•3HCl
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLi, H. et al., 2013. J. Neurosci. 33, 3135.
Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.