The quantity field is empty. Please enter a quantity of 1 or more to add items to your cart.
Description
Overview
Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett.17, 745. Caine, S. B. et al. 2002. J. Neurosci.22, 2977. Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett.17, 745. Caine, S. B. et al. 2002. J. Neurosci.22, 2977. Pillai, G. et al. 1998. Neuropharmacol.337, 983.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Selective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
Form
White solid
CAS number
81226-60-0
Chemical formula
C₂₀H₂₁ClN₂O
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett.17, 745. Caine, S. B. et al. 2002. J. Neurosci.22, 2977. Pillai, G. et al. 1998. Neuropharmacol.337, 983.
