505879 L-741,626 - CAS 81226-60-0 - Calbiochem

L-741,626 - CAS 81226-60-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626

Primary Target: D₂
505879
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₁ClN₂O 81226-60-0

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.05879.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewSelective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
          Catalogue Number505879
          Brand Family Calbiochem®
          SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
          References
          ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
          Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
          Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
          Product Information
          CAS number81226-60-0
          FormWhite solid
          Hill FormulaC₂₀H₂₁ClN₂O
          Chemical formulaC₂₀H₂₁ClN₂O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetD₂
          Primary Target K<sub>i</sub>7.1 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          L-741,626 - CAS 81226-60-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Grundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
          Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
          Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-September-2013 JSW
          SynonymsDopamine D₂ Receptor Antagonist, L-741,626, L-741626, L741626
          DescriptionSelective dopamine D2 receptor antagonist that is shown to reversibly block agonist-induced activation of GIRK currents. Reported to have a 15-fold selectivity for D2R over D3R in vitro. Inhibition of 3H-spirperone binding to cloned rat Dopamine receptors show the following Ki values: D2R (7.1 nM), D3R (155 nM), D4R (596 nM). Commonly used D2 inhibitor in addiction research.
          FormWhite solid
          CAS number81226-60-0
          Chemical formulaC₂₀H₂₁ClN₂O
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesGrundt, P. et al. 2007. Bioorg. Med. Chem. Lett. 17, 745.
          Caine, S. B. et al. 2002. J. Neurosci. 22, 2977.
          Pillai, G. et al. 1998. Neuropharmacol. 337, 983.