420360 KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem

420360
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Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₅N₃O₆S₂ 199666-03-0

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420360-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki = 4.8 nM; IC50 = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361).
      Catalogue Number420360
      Brand Family Calbiochem®
      SynonymsDimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048
      References
      ReferencesCampesan, S., et al. 2011. Chem. Biol. 21, 961.
      Zwilling, D., et al. 2011. Cell 145, 863.
      Giorgini, F., et al. 2005. Nat. Genet. 37, 526.
      Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771,
      Rover, S., et al. 1997. J. Med. Chem. 40, 4378.
      Product Information
      CAS number199666-03-0
      FormYellow solid
      Hill FormulaC₁₇H₁₅N₃O₆S₂
      Chemical formulaC₁₇H₁₅N₃O₆S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      420360

      References

      Reference overview
      Campesan, S., et al. 2011. Chem. Biol. 21, 961.
      Zwilling, D., et al. 2011. Cell 145, 863.
      Giorgini, F., et al. 2005. Nat. Genet. 37, 526.
      Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771,
      Rover, S., et al. 1997. J. Med. Chem. 40, 4378.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2012 JSW
      SynonymsDimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048
      DescriptionA cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki = 4.8 nM; IC50 = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number199666-03-0
      Chemical formulaC₁₇H₁₅N₃O₆S₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (12.5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCampesan, S., et al. 2011. Chem. Biol. 21, 961.
      Zwilling, D., et al. 2011. Cell 145, 863.
      Giorgini, F., et al. 2005. Nat. Genet. 37, 526.
      Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771,
      Rover, S., et al. 1997. J. Med. Chem. 40, 4378.