420134 JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable - Calbiochem

420134
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₂₅H₂₂₀N₅₂O₂₇

Pricing & Availability

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420134-2MG
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      Plastic ampoule 2 mg
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      Description
      OverviewThe non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.
      Catalogue Number420134
      Brand Family Calbiochem®
      SynonymsH₂N-YGRKKRRQRRR-RPKRPTTLNLF-NH₂, TAT₃₈₋₄₈ -Truncated Inhibitor based on JNK-Interacting Protein 1
      References
      ReferencesGuan, Q.H., et al. 2006. Neuroscience, 139, 609.
      Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett. 8, 550.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₂₅H₂₂₀N₅₂O₂₇
      Chemical formulaC₁₂₅H₂₂₀N₅₂O₂₇
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJNK
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      420134

      References

      Reference overview
      Guan, Q.H., et al. 2006. Neuroscience, 139, 609.
      Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett. 8, 550.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-July-2008 RFH
      SynonymsH₂N-YGRKKRRQRRR-RPKRPTTLNLF-NH₂, TAT₃₈₋₄₈ -Truncated Inhibitor based on JNK-Interacting Protein 1
      DescriptionThe non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₂₅H₂₂₀N₅₂O₂₇
      Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGuan, Q.H., et al. 2006. Neuroscience, 139, 609.
      Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
      Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett. 8, 550.
      Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.