IL008 Interleukin-8 Protein, Recombinant human, (72 amino acid form)

IL008
25 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesPurity
      CULT Human Greater than 98% by SDS-PAGE and HPLC analysis
      Description
      Catalogue NumberIL008
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterleukin-8 Protein, Recombinant human, (72 amino acid form)
      OverviewHuman interleukin-8 (IL-8) is an 8.4 kDa protein containing 72 amino acid residues. It promotes neutrophil chemotaxis and degranulation. The 72 amino acid IL-8 is the predominant form secreted by monocytes and lymphocytes.
      Alternate Names
      • IL-8
      References
      Product Information
      PresentationLyophilized powder with no additives.
      Quality LevelMQ100
      Applications
      ApplicationThe recombinant Human interleukin-8 protein (or IL-8 protein) is an 8.4 kDa protein containing 72 amino acid residues.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis
      Specific ActivityHuman IL-8 produces chemotaxis over a wide concentration range in an assay using human peripheral blood neutrophils. Significant chemotaxis was achieved using a concentration of 10-100 ng/mL.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
      Gene Symbol
      • IL8
      • GCP-1
      • emoctakin
      • MDNCF
      • NAP1
      • CXCL8
      • AMCF-I
      • IL-8
      • Emoctakin
      • TSG-1
      • NAP-1
      • LYNAP
      • MONAP
      • GCP1
      • SCYB8
      • LUCT
      • K60
      • LECT
      • 3-10C
      • b-ENAP
      • NAF
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10145 # IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
      SIZE: 99 amino acids; 11098 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Secreted.
      PTM: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.
      SIMILARITY: SwissProt: P10145 ## Belongs to the intercrine alpha (chemokine CxC) family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted IL-8 should be stored in undiluted aliquots at -20°C for up to six months.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interleukin-8 Protein, Recombinant human, (72 amino acid form) SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-8 Protein, Recombinant human, (72 amino acid form) Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM) - 24466732446673
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM) - 21434542143454
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)2477834
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)2972374
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)2991004
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)3063846
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)2867538
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)3072347
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)2913489
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM) - 23200202320020

      Data Sheet

      Title
      RECOMBINANT HUMAN INTERLEUKIN-8 (72 AMINO ACID FORM)

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors