IL038 Interleukin-1β Protein, Recombinant human

IL038
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesPurity
      CULT Human Greater than 98% by SDS-PAGE and HPLC analysis.Endotoxin level is less than 0..1 ng per μg (1EU//ug) off human IL-1beta..
      Description
      Catalogue NumberIL038
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterleukin-1β Protein, Recombinant human
      OverviewInterleukin-1beta (IL-1beta) is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T-cells. Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.
      Alternate Names
      • IL-1beta
      References
      Product Information
      PresentationSterile filtered and lyophilized from 10 mM Tris, pH 8.2 with no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThe recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cells.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, human IL-1beta is fully biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Leukocytes.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analysis.Endotoxin level is less than 0..1 ng per μg (1EU//ug) off human IL-1beta..
      Specific ActivityChemicon's human IL-1beta is fully biologically active when compared to standards. The ED(50) as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is < 0.001 ng/mL corresponding to a specific activity of > 1 x 10e9 units/mg.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
      Gene Symbol
      • IL1B
      • IL1F2
      • pro-interleukin-1-beta
      • IL1-BETA
      • Catabolin
      • IL-1
      • IL-1B
      • catabolin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01584 # Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
      SIZE: 269 amino acids; 30748 Da
      SUBUNIT: Monomer.
      SUBCELLULAR LOCATION: Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
      DOMAIN: SwissProt: P01584 The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
      SIMILARITY: Belongs to the IL-1 family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized human IL-1beta, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted human IL-1beta should be stored in undiluted aliquots at -20°C for up to six months.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interleukin-1β Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-1β Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN INTERLEUKIN-1#946; - 21459222145922
      RECOMBINANT HUMAN INTERLEUKIN-1#946; - 20268432026843
      RECOMBINANT HUMAN INTERLEUKIN-1B2914570
      RECOMBINANT HUMAN INTERLEUKIN-1B2886684
      RECOMBINANT HUMAN INTERLEUKIN-1b - 20318042031804
      RECOMBINANT HUMAN INTERLEUKIN-1b - 20583262058326
      RECOMBINANT HUMAN INTERLEUKIN-1b - 22193042219304
      RECOMBINANT HUMAN INTERLEUKIN-1b - 22999572299957
      RECOMBINANT HUMAN INTERLEUKIN-1ß -28559272855927
      RECOMBINANT HUMAN INTERLEUKIN-1β2876885

      Data Sheet

      Title
      RECOMBINANT HUMAN INTERLEUKIN-1beta

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors