01-172 Interferon-gamma (IFNγ)

01-172
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSource
      CULT Human Recombinant Human Interferon-gamma
      Description
      Catalogue Number01-172
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionInterferon-gamma (IFNγ)
      References
      Product Information
      PresentationLyophilized from PBS, pH 7.4
      Applications
      ApplicationThis Interferon-gamma (IFNγ) protein is available in a 100 µg format.
      Key Applications
      • Cell Culture
      Biological Information
      SourceRecombinant Human Interferon-gamma
      Entrez Gene Number
      Gene Symbol
      • IFNG
      • IFN-gamma
      • IFI
      • IFG
      Purification MethodSterilized through a 0.2 micron membrane filter
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01579 # Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
      SIZE: 166 amino acids; 19348 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
      PTM: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
      DISEASE: SwissProt: P01579 # In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
      SIMILARITY: SwissProt: P01579 ## Belongs to the type II (or gamma) interferon family.
      Stem Cell Type
      • Mesenchymal Stem Cells
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in a biological activity assay.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interferon-gamma (IFNγ) Certificates of Analysis

      TitleLot Number
      IFN-g (Interferon-g) (recombinant protein expressed in E. coli) - 19581081958108
      IFN-g (Interferon-g) - DAM1570813DAM1570813
      IFN-g (Interferon-g) - DAM1780346DAM1780346
      IFN-g (Interferon-g) - JBC1863396JBC1863396
      IFN-y (Interferon-y) -
      IFN-y (Interferon-y) - DAM1557437DAM1557437
      IFNgamma; - 06090408280609040828
      IFNgamma; - 1587115871
      IFNgamma; - 1659716597
      IFNgamma; - 1865918659

      References

      Reference overviewApplicationPub Med ID
      Tumor necrosis factor alpha (TNFalpha) promotes growth of virulent Mycobacterium tuberculosis in human monocytes iron-mediated growth suppression is correlated with decreased release of TNFalpha from iron-treated infected monocytes
      Byrd, T. F.
      J Clin Invest, 99:2518-29 (1997)  1997

      Cell Culture9153296 9153296
      Co-regulation and physical association of the 67-kDa monomeric laminin receptor and the alpha6beta4 integrin
      Ardini, E., et al
      J Biol Chem, 272:2342-5 (1997)  1997

      Cell Culture8999943 8999943
      The molecular cell biology of interferon-gamma and its receptor.
      Farrar, M A and Schreiber, R D
      Annu. Rev. Immunol., 11: 571-611 (1993)  1993

      Show Abstract
      8476573 8476573

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors