IF002 Interferon-γ Protein, Recombinant human

IF002
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Human Human, expressed in E.coli Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of IFN-gamma.
      Description
      Catalogue NumberIF002
      ReplacesIF3
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInterferon-γ Protein, Recombinant human
      OverviewInterferon-g (IFN-gamma) is a lymphoid factor which possesses potent anti-viral activity. It has also been shown to stimulate macrophages and NK cells. Human IFN-gamma is a 16.7 kDa protein containing 143 amino acid residues.
      References
      Product Information
      PresentationSterile filtered, lyophilized from 10 mM sodium phosphate, pH 7.4.
      Quality LevelMQ100
      Applications
      ApplicationThe Interferon-g protein (or IFN-gamma protein) is a lymphoid factor which possesses potent anti-viral activity.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, IFN-gamma exerts its biological activity in the concentration range of 0.1 to 10 ng/mL. Responding cells are (partial list): Lymphocytes.
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg) of IFN-gamma.
      SourceHuman, expressed in E.coli
      Specific ActivityHuman IFN-gamma is fully biologically active when compared to standards. The ED(50) as determined in a viral resistance assay is <= 0.05 ng/mL corresponding to a specific activity of >= 2 x 10(E7) units/mg.
      Entrez Gene Number
      Gene Symbol
      • IFNG
      • IFN-gamma
      • IFI
      • IFG
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01579 # Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
      SIZE: 166 amino acids; 19348 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
      PTM: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
      DISEASE: SwissProt: P01579 # In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
      SIMILARITY: SwissProt: P01579 ## Belongs to the type II (or gamma) interferon family.
      Stem Cell Type
      • Mesenchymal Stem Cells
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized IFN-g, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in 1x PBS, pH 8.0 to a concentration of 0.5-1.0 mg/mL. Note: Further dilutions should be made into RPMI + 10% FCS or 5% HSA and stored at 4°C for 1 week or -20°C for future use. Reconstituted material should be stored in undiluted aliquots at -20°C for up to six months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Interferon-γ Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Interferon-γ Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN INTERFERON-#947; - 21200102120010
      RECOMBINANT HUMAN INTERFERON-g - 20458442045844
      RECOMBINANT HUMAN INTERFERON-g - 20631512063151
      RECOMBINANT HUMAN INTERFERON-g - 21960002196000
      RECOMBINANT HUMAN INTERFERON-g - 22956402295640
      RECOMBINANT HUMAN INTERFERON-g - 23090182309018
      RECOMBINANT HUMAN INTERFERON-y2942616
      RECOMBINANT HUMAN INTERFERON-y2915313
      RECOMBINANT HUMAN INTERFERON-y2886670
      RECOMBINANT HUMAN INTERFERON-γ3103619

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors