GF138 Insulin-like Growth Factor-I Protein, Recombinant human

GF138
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Human E.coli Greater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-1.
      Description
      Catalogue NumberGF138
      ReplacesGF006
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionInsulin-like Growth Factor-I Protein, Recombinant human
      OverviewInsulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor which stimulates the proliferation of a wide range of cell types including muscle, bone, and cartilage tissue. Human IGF-I is a 7.6 kDa protein containing 70 amino acid residues.
      Alternate Names
      • IGF-I
      Background InformationInsulin-like Growth Factor (IGF-1) is a polypeptide endocrine hormone similar in structure to insulin. Stimulated by growth hormone and produced primarily in the liver, it binds to the IGF-1 receptor with a high affinity and to the insulin receptor with a much lower affinity. The tyrosine kinase IGF-1 receptor is a potent activator of the Akt signaling pathway, which drives a variety of processes including cell growth and division and apoptosis inhibition. Because approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP), extraction is required to measure extracellular protein concentrations. Increased levels of IGF-1 have been correlated with an increased risk of cancer. In addition, while involved in reducing hemoglobin A1C levels and daily insulin consumption in types 1 and 2 diabetes, these increased levels have been also implicated in the development of diabetic retinopathy. Drugs have been developed as replacement therapy for severe primary IGF-1 deficiency, a group of diseases in which patients do not respond to growth hormone therapy.
      References
      Product Information
      PresentationLyophilized from sterile filtered 10 mM Sodium Phosphate, pH 6, containing no additives.
      Quality LevelMQ100
      Applications
      ApplicationInsulin Like Growth Factor-I (IGF-I) is a polypeptide growth factor which stimulates the proliferation of a wide range of cell types including muscle, bone & cartilage tissue.
      Key Applications
      • Cell Culture
      Application NotesFor most in vitro applications, IGF-I exerts its biological activity in the concentration range of 0.2 to 20.0 ng/mL. Responding cells are (partial list): bone, muscle cells, CHO cells.

      Optimal working dilutions must be determined by end user.
      Biological Information
      PurityGreater than 98% by SDS-PAGE. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of IGF-1.
      SourceE.coli
      Specific ActivityHuman IGF-I is fully biologically active when compared to standards. The ED50 as determined by a cell proliferation assay using FDC-P1 cells is <=10.0 ng/mL corresponding to a specific activity of >=1 x 10e5 units/mg.
      Entrez Gene Number
      Gene Symbol
      • IGF1
      • Somatomedin-C
      • IGF-IB
      • IGF-IA
      • IBP1
      • MGF
      • IGFI
      UniProt Number
      Stem Cell Type
      • Hematopoietic Stem Cells
      • Mesenchymal Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized IGF-I, though stable at room temperature, is best stored at -20°C for up to 12 months from date of receipt. After a quick spin, reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4°C for one week or at -20°C for future use. Reconstituted IGF-I should be stored in undiluted aliquots at -20°C for up to six months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Insulin-like Growth Factor-I Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      Insulin-like Growth Factor-I Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN INSULIN LIKE GROWTH FACTOR-I3044985
      RECOMBINANT HUMAN INSULIN LIKE GROWTH FACTOR-I2814401
      RECOMBINANT HUMAN INSULIN LIKE GROWTH FACTOR-I - 22110212211021
      RECOMBINANT HUMAN INSULIN LIKE GROWTH FACTOR-I - 32848983284898
      RECOMBINANT HUMAN INSULIN LIKE GROWTH FACTOR-I -25004782500478
      RECOMBINANT HUMAN INSULIN LIKE GROWTH FACTOR-I -27009642700964

      Data Sheet

      Title
      RECOMBINANT HUMAN INSULIN LIKE GROWTH FACTOR-I

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors