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534342 InhA Inhibitor, NITD-916 - Calbiochem

534342
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₂₅NO₂

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable, orally available, highly lipophilic 4-hydroxy-2-pyridone derivative that directly binds to the enoyl-substrate binding pocket of Mycobaterial enoyl reductase inhA in an NADH-dependent manner and inhibits its activity (IC50 = 570 nM). Shown to be about 5 to 8 times more potent ((MIC50 = 40 to 160 nM in multi-drug resistant strains of Mycobacterium) than isoniazid (MIC50 = 330 nM) and PA-824 (MIC50 = 400 nM). Exhibits in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. Exhibits low to moderate metabolic clearance in mouse and human hepatic microsomes. Suggested to inhibit the fatty acid elongation step that blocks the biosynthesis of mycolic acids and weakens the cell wall mycolyl-arabinogalactan-peptidoglycan complex, and ultimately lysis of Mycobacterium.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number534342
      Brand Family Calbiochem®
      Synonyms6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one , Enoyl-acyl Carrier Protein Reductase Inhibitor, NITD-916, Enoyl-ACP reductase, NITD-916
      References
      ReferencesManjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.
      Product Information
      FormWhite solid
      Hill FormulaC₂₀H₂₅NO₂
      Chemical formulaC₂₀H₂₅NO₂
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhA
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InhA Inhibitor, NITD-916 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Manjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-August-2017 JSW
      Synonyms6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one , Enoyl-acyl Carrier Protein Reductase Inhibitor, NITD-916, Enoyl-ACP reductase, NITD-916
      DescriptionA cell-permeable, orally available, highly lipophilic 4-hydroxy-2-pyridone derivative that directly binds to the enoyl-substrate binding pocket of Mycobaterial enoyl reductase inhA in an NADH-dependent manner and inhibits its activity (IC50 = 570 nM). Shown to be about 5 to 8 times more potent ((MIC50 = 40 to 160 nM in multi-drug resistant strains of Mycobacterium) than isoniazid (MIC50 = 330 nM) and PA-824 (MIC50 = 400 nM). Exhibits in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. Exhibits low to moderate metabolic clearance in mouse and human hepatic microsomes. Suggested to inhibit the fatty acid elongation step that blocks the biosynthesis of mycolic acids and weakens the cell wall mycolyl-arabinogalactan-peptidoglycan complex, and ultimately lysis of Mycobacterium.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₅NO₂
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesManjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.