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506072 InSolution™ Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
686770-61-6C₂₂H₁₈N₄O₂S₃

Products

Catalog NumberPackaging Qty/Pack
5.06072.0001 Glass bottle 5 mg
Description
Catalogue Number506072
Brand Family Calbiochem®
SynonymsN-(6-Methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)acetamide, Wnt Pathway Inhibitor II InSolution, Inhibitor of Wnt Production-2, Porcn Inhibitor I InSolution, InSolution Wnt Antagonist II, IWP-2, Wnt Antagonist II, IWP-2 InSolution
References
ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Product Information
CAS number686770-61-6
FormLiquid
FormulationA 10 mM (5 mg/1.07 ml) sterile-filtered solution of Wnt Antagonist II, IWP-2 (Cat. No. 681671) in DMSO.
Hill FormulaC₂₂H₁₈N₄O₂S₃
Chemical formulaC₂₂H₁₈N₄O₂S₃
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPorcn
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Slight warming may be required upon initial thaw.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.06072.0001 04055977243055

Documentation

InSolution™ Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Chen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2014 JSW
SynonymsN-(6-Methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)acetamide, Wnt Pathway Inhibitor II InSolution, Inhibitor of Wnt Production-2, Porcn Inhibitor I InSolution, InSolution Wnt Antagonist II, IWP-2, Wnt Antagonist II, IWP-2 InSolution
DescriptionA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.
FormLiquid
FormulationA 10 mM (5 mg/1.07 ml) sterile-filtered solution of Wnt Antagonist II, IWP-2 (Cat. No. 681671) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number686770-61-6
Chemical formulaC₂₂H₁₈N₄O₂S₃
Structure formulaStructure formula
Purity≥99% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Slight warming may be required upon initial thaw.
Toxicity Standard Handling
ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.