559397 InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem

559397
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₀H₁₄FN₃O 152121-30-7

Pricing & Availability

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559397-1ML
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      Glass bottle 1 ml
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      Description
      Catalogue Number559397
      Brand Family Calbiochem®
      SynonymsInSolution™ p38 MAP Kinase Inhibitor II
      References
      ReferencesAjizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
      Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
      Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
      Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
      Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
      Lee, L.C., et al. 1994. Nature 372, 739.
      Product Information
      CAS number152121-30-7
      ATP CompetitiveY
      FormLiquid
      FormulationA 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
      Hill FormulaC₂₀H₁₄FN₃O
      Chemical formulaC₂₀H₁₄FN₃O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP38β
      Primary Target IC<sub>50</sub>16 nM
      Primary Target K<sub>i</sub>16 nM; 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
      Purity≥98% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      559397

      References

      Reference overview
      Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
      Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
      Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
      Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
      Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
      Lee, L.C., et al. 1994. Nature 372, 739.

      Brochure

      Title
      In Solution!" Product Flyer
      MAPK Pathway Poster ( 750 KB )

      Citations

      Title
    • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      SynonymsInSolution™ p38 MAP Kinase Inhibitor II
      DescriptionA potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.
      FormLiquid
      FormulationA 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Concentration Label Please refer to vial label for lot-specific concentration
      CAS number152121-30-7
      Chemical formulaC₂₀H₁₄FN₃O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesAjizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
      Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
      Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
      Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
      Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
      Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
      Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
      Lee, L.C., et al. 1994. Nature 372, 739.
      Citation
    • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.