557521 InSolution™ Ro-31-8220 - Calbiochem

557521
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₅H₂₃N₅O₂S • CH₃SO₃H

Pricing & Availability

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557521-500UG
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      Plastic ampoule 500 μg
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      Description
      Catalogue Number557521
      Brand Family Calbiochem®
      Synonyms3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate
      References
      Product Information
      ATP CompetitiveY
      FormClear orange-brown liquid
      FormulationA 5 mM (500 µg/181 µl) solution of Ro-31-8220 (Cat. No. 557520) in H₂O.
      Hill FormulaC₂₅H₂₃N₅O₂S • CH₃SO₃H
      Chemical formulaC₂₅H₂₃N₅O₂S • CH₃SO₃H
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>10 nM against protein kinase C (PKC); 6.8 nM against GSK-3 in primary adipocytes
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Ro-31-8220 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Ro-31-8220 - Calbiochem Certificates of Analysis

      TitleLot Number
      557521

      Brochure

      Title
      In Solution!" Product Flyer
      PKC Pathway Poster PDF ( 676 KB )

      Citations

      Title
    • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2008 RFH
      Synonyms3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate
      DescriptionA competitive, selective inhibitor for protein kinase C (IC50 = 10 nM) over protein kinase A (IC50 = 900 nM), Ca2+/calmodulin-dependent protein kinase (IC50 = 17 µM) and phosphorylase protein kinase. Inhibits TPA induced p47 phosphorylation in platelets (IC50 = 700 nM). Also inhibits CD3 downregulation in T cells (IC50 = 500 nM).
      FormClear orange-brown liquid
      FormulationA 5 mM (500 µg/181 µl) solution of Ro-31-8220 (Cat. No. 557520) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₂₃N₅O₂S • CH₃SO₃H
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      Citation
    • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.