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557404 InSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
577784-91-9C₁₉H₁₅Cl₂N₃O₂S₂

Products

Catalog NumberPackaging Qty/Pack
557404-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available.
Catalogue Number557404
Brand Family Calbiochem®
SynonymsN-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide, 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide
References
ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.
Product Information
CAS number577784-91-9
FormLiquid
FormulationA 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO.
Hill FormulaC₁₉H₁₅Cl₂N₃O₂S₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRNA Polymerase III
Primary Target IC<sub>50</sub>27 µ
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
557404-5MG 04055977268065

Documentation

InSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem Certificates of Analysis

TitleLot Number
557404

References

Reference overview
Wu, L., et al. 2003. Euk. Cell 2, 256.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-September-2012 JSW
SynonymsN-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide, 2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide
DescriptionA cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available.
FormLiquid
FormulationA 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number577784-91-9
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Standard Handling
ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.