Product Information
Applications
Biological Information
Primary Target Thrombin
Purity≥88% by HPLC
Physicochemical Information
Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ PPACK, 2HCl - CAS 74392-58-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ PPACK, 2HCl - CAS 74392-58-8 - Calbiochem Certificates of Analysis

TitleLot Number
508773

References

Reference overview
Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-September-2017 JSW
SynonymsD-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone, 2HCl, H-D-Phe-Pro-Arg-chloromethylketone, 2HCl, PPACK, dihydrochloride InSolution™
DescriptionExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.
FormLiquid
FormulationA 25 mM (5 mg/357 µl) sterile-filtered solution of PPACK, 2HCl (Cat. No. 520222) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number74392-58-8
Chemical formulaC₂₁H₃₁ClN₆O₃ • 2HCl
Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
Purity≥88% by HPLC
Storage ≤ -70°C
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors