513036 InSolution™ PD 158780 - CAS 171179-06-9 - Calbiochem

513036
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₄H₁₂BrN₅ 171179-06-9

Pricing & Availability

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513036-500UG
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      Plastic ampoule 500 μg
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      Description
      Catalogue Number513036
      Brand Family Calbiochem®
      References
      ReferencesCunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468.
      Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742.
      Product Information
      CAS number171179-06-9
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513035) in DMSO.
      Hill FormulaC₁₄H₁₂BrN₅
      Chemical formulaC₁₄H₁₂BrN₅
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub> 8 pM against EGFR tyrosine kinase activity; 49 nM, 52 nM, against heregulin-stimulated autophosphorylation in SK-BR-3 and MDA-MB-453 breast carcinomas, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ PD 158780 - CAS 171179-06-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ PD 158780 - CAS 171179-06-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      513036

      References

      Reference overview
      Cunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468.
      Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742.

      Brochure

      Title
      In Solution!" Product Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2007 JSW
      DescriptionA potent inhibitor of the EGFR tyrosine kinase activity (8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 =49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells.
      FormLiquid
      FormulationA 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513035) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number171179-06-9
      Chemical formulaC₁₄H₁₂BrN₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesCunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468.
      Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742.