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401485 InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem

401485
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₉H₈N₂OS₂

Pricing & Availability

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401485-1MG
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      Plastic ampoule 1 mg
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      Description
      Catalogue Number401485
      Brand Family Calbiochem®
      References
      ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
      Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
      Product Information
      ATP CompetitiveY
      FormClear to pale yellow Liquid
      FormulationA 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
      Hill FormulaC₉H₈N₂OS₂
      Chemical formulaC₉H₈N₂OS₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIKK-2
      Primary Target IC<sub>50</sub>~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem Certificates of Analysis

      TitleLot Number
      401485

      References

      Reference overview
      Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
      Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

      Brochure

      Title
      In Solution!" Product Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      DescriptionA cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
      FormClear to pale yellow Liquid
      FormulationA 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₉H₈N₂OS₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Irritant
      ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
      Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.