371962 InSolution™ H-89, Dihydrochloride - Calbiochem

371962
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₀H₂₀BrN₃O₂S

Pricing & Availability

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371962-1MG
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      Plastic ampoule 1 mg
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      Description
      Catalogue Number371962
      Brand Family Calbiochem®
      SynonymsN-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
      References
      ReferencesLeemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
      Davies, S.P. et al. 2000. Biochem. J. 351, 95.
      de Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
      Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
      Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
      Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
      Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371963) in DMSO.
      Hill FormulaC₂₀H₂₀BrN₃O₂S
      Chemical formulaC₂₀H₂₀BrN₃O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM).
      Biological Information
      Primary TargetPKA
      Primary Target K<sub>i</sub>48 nM against protein kinase A
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ H-89, Dihydrochloride - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ H-89, Dihydrochloride - Calbiochem Certificates of Analysis

      TitleLot Number
      371962

      References

      Reference overview
      Leemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
      Davies, S.P. et al. 2000. Biochem. J. 351, 95.
      de Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
      Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
      Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
      Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
      Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.

      Brochure

      Title
      In Solution!" Product Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-September-2007 JSW
      SynonymsN-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
      DescriptionA solution of H-89, Dihydrochloride (Cat. No. 371963) in anhydrous DMSO. H-89 is a cell-permeable selective and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 µM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 µM), protein kinase C (Ki = 31.7 µM), casein kinase I (Ki = 38.3 µM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 µM) by blocking the action of Rho kinase II.
      FormLiquid
      FormulationA 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371963) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₀BrN₃O₂S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesLeemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
      Davies, S.P. et al. 2000. Biochem. J. 351, 95.
      de Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
      Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
      Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
      Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
      Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.