365253 InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem

365253
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₄H₁₈N₄O 136194-77-9

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365253-1ML
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      Plastic ampoule 1 ml
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      Description
      Catalogue Number365253
      Brand Family Calbiochem®
      SynonymsGo 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
      References
      ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
      Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
      Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
      Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.
      Product Information
      CAS number136194-77-9
      ATP CompetitiveY
      FormLiquid
      FormulationA 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
      Hill FormulaC₂₄H₁₈N₄O
      Chemical formulaC₂₄H₁₈N₄O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      365253

      References

      Reference overview
      Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
      Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
      Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
      Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.

      Brochure

      Title
      In Solution!" Product Flyer
      PKC Pathway Poster PDF ( 676 KB )

      Citations

      Title
    • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-July-2008 RFH
      SynonymsGo 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
      DescriptionInhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.
      FormLiquid
      FormulationA 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number136194-77-9
      Chemical formulaC₂₄H₁₈N₄O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
      Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
      Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
      Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.
      Citation
    • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.