401250 Ilimaquinone - CAS 71678-03-0 - Calbiochem

401250
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₂H₃₀O₄ 71678-03-0

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401250-100UG
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      Plastic ampoule 100 μg
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      Description
      OverviewA cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties. Induces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules. Inhibits cellular methylations through its interaction with S-adenosylhomocysteinase. Blocks the cytotoxicity of ricin and diphtheria toxin. Acts as an inhibitor of the RNase H activity of HIV-1.
      Catalogue Number401250
      Brand Family Calbiochem®
      Synonyms3-[(Decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-napthyl)methyl]-2-hydroxy-5-methoxybenzoquinone, IQ
      References
      ReferencesRadeke, H.S., et al. 1999. Chem. Biol. 6, 639.
      Radeke, H.S., and Snapper, M.L. 1998. Bioorg. Med. Chem. 6, 1227.
      Jamora, C., et al. 1997. Cell 91, 617.
      Nambiar, M.P., and Wu, H.C. 1995. Exp. Cell Res. 219, 671.
      Loya, S., and Hizi, A. 1993. J. Biol. Chem. 268, 9323.
      Takizawa, P.A., et al. 1993. Cell 73, 1079.
      Veit, B., et al. 1993. J. Cell Biol. 122, 1197.
      Product Information
      CAS number71678-03-0
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₂₂H₃₀O₄
      Chemical formulaC₂₂H₃₀O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInduces a complete and reversible breakdown of Golgi membranes into smaller vesicular structures and causes depolymerization of microtubules.
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ilimaquinone - CAS 71678-03-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Radeke, H.S., et al. 1999. Chem. Biol. 6, 639.
      Radeke, H.S., and Snapper, M.L. 1998. Bioorg. Med. Chem. 6, 1227.
      Jamora, C., et al. 1997. Cell 91, 617.
      Nambiar, M.P., and Wu, H.C. 1995. Exp. Cell Res. 219, 671.
      Loya, S., and Hizi, A. 1993. J. Biol. Chem. 268, 9323.
      Takizawa, P.A., et al. 1993. Cell 73, 1079.
      Veit, B., et al. 1993. J. Cell Biol. 122, 1197.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      Synonyms3-[(Decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-napthyl)methyl]-2-hydroxy-5-methoxybenzoquinone, IQ
      DescriptionA cell-permeable marine sponge metabolite that induces complete and reversible breakdown of Golgi membranes into smaller vesicular structures, possibly through the activation of heterotrimeric G-proteins. Blocks protein transport at the cis-Golgi and depolymerizes microtubules. Also possesses anti-HIV activity and the ability to inhibit the cytotoxicity of ricin and diphtheria toxin.
      FormRed solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number71678-03-0
      Chemical formulaC₂₂H₃₀O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Standard Handling
      ReferencesRadeke, H.S., et al. 1999. Chem. Biol. 6, 639.
      Radeke, H.S., and Snapper, M.L. 1998. Bioorg. Med. Chem. 6, 1227.
      Jamora, C., et al. 1997. Cell 91, 617.
      Nambiar, M.P., and Wu, H.C. 1995. Exp. Cell Res. 219, 671.
      Loya, S., and Hizi, A. 1993. J. Biol. Chem. 268, 9323.
      Takizawa, P.A., et al. 1993. Cell 73, 1079.
      Veit, B., et al. 1993. J. Cell Biol. 122, 1197.